Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA–protease interactions
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چکیده
منابع مشابه
into avian influenza virus pathogenicity : the hemagglutinin 1 precursor HA 0 of H 16 subtype has an α - helix structure in its cleavage 2 site with an inefficient HA 1 / HA 2 cleavage
4 Xishan Lu, Yi Shi, Feng Gao, Haixia Xiao, Ming Wang, Jianxun Qi and George 5 F Gao 6 7 College of Veterinary Medicine, China Agricultural University, Beijing 100193, China 8 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of 9 Microbiology, Chinese Academy of Sciences, Beijing 100101, China 10 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese A...
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Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to occur naturally only in these HA subtypes, little is known about the genetic basis for the acquisition of the polybasic HA cleavage site. Here...
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Human infections with H7 subtype influenza virus have been reported, including an H7N7 outbreak in Netherlands in 2003 and H7N9 infections in China in 2013. Previously, we reported murine monoclonal antibodies (mAbs) that recognize the antigenic site A of H7 hemagglutinin (HA). To better understand protective immunity of H7 vaccines and vaccine candidate selection, we used these mAbs to assess ...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2006
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2006.04.007